In the foregoing we have shown that the changing world poses a whole range of meta-scientific, including ethical, questions to the scientist, for whom washing their hands in innocence or ignorance is no option. Neither is it reasonable to find the right answers to these questions in solitude. One needs a critical and intellectual discourse with other scientists and scholars. In my view, national, regional and world academies of arts and sciences are the organisations par excellence to provide a platform for such a dialogue. I seriously hope they will take up this gauntlet.